Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Gelatin is formed when collagen becomes partly or completely...

Class:Id	Summation:1454743
_displayName	Gelatin is formed when collagen becomes partly or completely...
_timestamp	2012-10-29 15:21:16
created	[InstanceEdit:1454796] Jupe, S, 2011-07-18
literatureReference	[LiteratureReference:1454859] Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis [LiteratureReference:2537480] H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen [LiteratureReference:1602465] SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [LiteratureReference:2537535] Gelatinases A and B [LiteratureReference:1564207] Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens [LiteratureReference:2537496] Calprotectin inhibits matrix metalloproteinases by sequestration of zinc [LiteratureReference:1458419] Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates [LiteratureReference:2537473] Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins [LiteratureReference:1564149] Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein [LiteratureReference:1458404] Biochemical characterization of human collagenase-3 [LiteratureReference:2537508] Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain [LiteratureReference:2537525] Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain [LiteratureReference:2537513] Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts [LiteratureReference:2537521] Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme [LiteratureReference:2537509] Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP, and human MMP19 have a conserved unique cysteine in the catalytic domain
modified	[InstanceEdit:1454885] Jupe, S, 2011-07-18 [InstanceEdit:1458406] Jupe, S, 2011-07-21 [InstanceEdit:2537528] Jupe, S, 2012-10-29
text	Gelatin is formed when collagen becomes partly or completely uncoiled when compared with the regular triple helix structure of fibrillar collagen. In vivo, once collagens are initially cleaved into clasical 3/4 and 1/4 fragments (by collagenases) they rapidly denature at body temperature and are degraded by gelatinases and other nonspecific tissue proteinases (Chung et al. 2004) to a semi-solid colloid gel. MMP2 and MMP9 are the major gelatinases (Collier et al. 1988, Wilhelm et al. 1989) often referred to respectively as Gelatinase A and Gelatinase B (Murphy & Crabbe 1995). However many other MMPs have gelatinase activity, including MMP1 (Murphy et al. 1982, Isaksen & Fagerhol 2001, Chung et al. 2004), MMP3 (Chin et al. 1985, Isaksen & Fagerhol 2001), MMP7 (Isaksen & Fagerhol 2001), MMP8 (Isaksen & Fagerhol 2001) MMP10 (Sanches-Lopez et al. 1993), MMP12 (Chandler et al. 1996), MMP13 (Kn�uper et al. 1993, Isaksen & Fagerhol 2001), MMP16 (Shofuda et al. 1997), MMP17 (Wang et al. 1999), MMP18 (Spinucci et al. 1988), MMP19 (Stracke et al. 2000) and MMP22 (Yang & Kurkinen 1998).
(summation)	[BlackBoxEvent:1454757] Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 [Homo sapiens] [BlackBoxEvent:2537499] Gelatin degradation by MMP19 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Gelatin is formed when collagen becomes partly or completely... (1454743)