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Details on Person UniProt:O08532 Cacna2d1
| Class:Id | ReferenceGeneProduct:145412 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-1103 added on Fri February 6 2015;chain:25-957 added on Fri February 6 2015;chain:958-1103 added on Fri February 6 2015 |
| _displayName | UniProt:O08532 Cacna2d1 |
| _timestamp | 2023-11-03 16:00:24 |
| chain | signal peptide:1-24 chain:25-1103 chain:25-957 chain:958-1103 |
| checksum | 103773B4735120D4 |
| comment | FUNCTION The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity).SUBUNIT Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).INTERACTION Isoform 2A is expressed in skeletal muscle and aorta. Isoform 2B is expressed in brain. Isoform 2C is expressed in heart. Isoform 2D is expressed in heart and smooth muscle. Isoform 2E is expressed in smooth muscle. All five isoforms are expressed in the cardiovascular system.DOMAIN The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.PTM Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.MISCELLANEOUS Binds gabapentin, an antiepileptic drug.SIMILARITY Belongs to the calcium channel subunit alpha-2/delta family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Voltage-dependent calcium channel subunit alpha-2/delta-1 alternativeName: Voltage-gated calcium channel subunit alpha-2/delta-1 component recommendedName: Voltage-dependent calcium channel subunit alpha-2-1 /component component recommendedName: Voltage-dependent calcium channel subunit delta-1 /component |
| geneName | Cacna2d1 Cacna2 |
| identifier | O08532 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Calcium channel Calcium transport Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Membrane Metal-binding Phosphoprotein Reference proteome Signal Transmembrane Transmembrane helix Transport Voltage-gated channel |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cacna2d1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CA2D1_MOUSE O08533 O08534 O08535 O08536 |
| sequenceLength | 1103 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:145413] UniProt:O08532-2 Cacna2d1 [Mus musculus] [ReferenceIsoform:145414] UniProt:O08532-3 Cacna2d1 [Mus musculus] [ReferenceIsoform:145415] UniProt:O08532-4 Cacna2d1 [Mus musculus] [ReferenceIsoform:145416] UniProt:O08532-5 Cacna2d1 [Mus musculus] [ReferenceIsoform:401160] UniProt:O08532-1 Cacna2d1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9905923] Cacna2d1(25-957) [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:9905951] Cacna2d1(958-1103) [plasma membrane] [Mus musculus] |
| (referenceSequence) | [InterChainCrosslinkedResidue:9905941] Inter-chain Crosslink via L-cystine (cross-link) at 1059 and 404 [InterChainCrosslinkedResidue:9905942] Inter-chain Crosslink via L-cystine (cross-link) at 404 and 1059 |
| (secondReferenceSequence) | [InterChainCrosslinkedResidue:9905941] Inter-chain Crosslink via L-cystine (cross-link) at 1059 and 404 [InterChainCrosslinkedResidue:9905942] Inter-chain Crosslink via L-cystine (cross-link) at 404 and 1059 |
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No pathways have been reviewed or authored by UniProt:O08532 Cacna2d1 (145412)
