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Details on Person UniProt:O15519-11 CFLAR
| Class:Id | ReferenceIsoform:145335 |
|---|---|
| _chainChangeLog | chain:1-376 added on Fri February 6 2015;chain:377-480 added on Fri February 6 2015 |
| _displayName | UniProt:O15519-11 CFLAR |
| _timestamp | 2026-02-20 22:19:57 |
| chain | chain:1-376 chain:377-480 |
| checksum | 8C6D7E92AE1EB672 |
| comment | FUNCTION Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells (PubMed:31046799). Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.SUBUNIT TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9208847, PubMed:9326610). Interacts with RIPK1 (By similarity) (PubMed:9208847, PubMed:9326610, PubMed:9880531). Interacts with GMEB1 (PubMed:31046799).SUBUNIT (Microbial infection) Interacts with HBV protein X.INTERACTION Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.INDUCTION Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle.DOMAIN The caspase domain lacks the active site residues involved in catalysis.PTM Proteolytically processed by CASP8 generating subunit p43 and p12.PTM Deubiquitinated by USP40, leading to stabilization.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the peptidase C14A family. |
| description | recommendedName: CASP8 and FADD-like apoptosis regulator alternativeName: Caspase homolog shortName: CASH alternativeName: Caspase-eight-related protein shortName: Casper alternativeName: Caspase-like apoptosis regulatory protein shortName: CLARP alternativeName: Cellular FLICE-like inhibitory protein shortName: c-FLIP alternativeName: FADD-like antiapoptotic molecule 1 shortName: FLAME-1 alternativeName: Inhibitor of FLICE shortName: I-FLICE alternativeName: MACH-related inducer of toxicity shortName: MRIT alternativeName: Usurpin component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p43 /component component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p12 /component |
| geneName | CFLAR CASH CASP8AP1 CLARP MRIT |
| identifier | O15519 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Host-virus interaction Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CFLAR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004598] ENSEMBL:ENSG00000003402 CFLAR [Homo sapiens] |
| secondaryIdentifier | CFLAR_HUMAN B4DJE0 B7Z9F9 O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618 O43619 O43620 O60458 O60459 Q53TS6 Q54AF1 Q96TE4 Q9UEW1 |
| sequenceLength | 480 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O15519-11 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O15519-11 CFLAR (145335)
