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Details on Person UniProt:P10747-4 CD28
| Class:Id | ReferenceIsoform:145147 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Sat February 7 2015;chain:19-220 added on Sat February 7 2015 |
| _displayName | UniProt:P10747-4 CD28 |
| _timestamp | 2026-02-20 22:52:43 |
| chain | signal peptide:1-18 chain:19-220 |
| checksum | 1D9B6552A5878D0F |
| comment | FUNCTION Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets (PubMed:12196291, PubMed:1650475, PubMed:35397202). Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways (PubMed:21964608, PubMed:24665965, PubMed:7568038). In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells (PubMed:8617933).FUNCTION Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).SUBUNIT Homodimer; disulfide-linked (PubMed:35397202). Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70 (PubMed:12196291). Interacts with GRB2 (PubMed:24098653, PubMed:7568038). Interacts with PIK3R1 (PubMed:7568038). Interacts with PRKCQ (PubMed:21964608).SUBUNIT Interacts with CD40LG.INTERACTION Expressed in T-cells and plasma cells, but not in less mature B-cells.PTM Phosphorylated by LCK (PubMed:7568038). Dephosphorylated by PTPN11 (PubMed:36114179).PTM Tyrosine phosphorylated induced by CD40LG.DISEASE The disease may be caused by variants affecting the gene represented in this entry.ONLINE INFORMATION CD28 entry |
| description | recommendedName: T-cell-specific surface glycoprotein CD28 alternativeName: TP44 cdAntigenNameCD28/cdAntigenName |
| geneName | CD28 |
| identifier | P10747 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CD28 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004587] ENSEMBL:ENSG00000178562 CD28 [Homo sapiens] |
| secondaryIdentifier | CD28_HUMAN A8KAC1 Q13964 Q52M23 Q70WG0 Q8NI54 Q8NI55 Q8NI56 Q8WXJ2 Q9BYV0 |
| sequenceLength | 220 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P10747-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P10747-4 CD28 (145147)
