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Details on Person UniProt:P54285-2 Cacnb3
| Class:Id | ReferenceIsoform:145111 |
|---|---|
| _chainChangeLog | chain:1-484 added on Fri February 6 2015 |
| _displayName | UniProt:P54285-2 Cacnb3 |
| _timestamp | 2023-11-03 15:43:47 |
| chain | chain:1-484 |
| checksum | 56871A0B563A567E |
| comment | FUNCTION Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:24751537). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).SUBUNIT Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (PubMed:24751537).SUBCELLULAR LOCATION Detected in the inner plexiform layer in the retina (at protein level).SIMILARITY Belongs to the calcium channel beta subunit family. |
| description | recommendedName: Voltage-dependent L-type calcium channel subunit beta-3 shortName: CAB3 alternativeName: Calcium channel voltage-dependent subunit beta 3 shortName: CCHB3 |
| geneName | Cacnb3 Cacnlb3 |
| identifier | P54285 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Calcium channel Calcium transport Cytoplasm Ion channel Ion transport Phosphoprotein Reference proteome SH3 domain Transport Voltage-gated channel |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cacnb3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CACB3_MOUSE G5E821 |
| sequenceLength | 484 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | P54285-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:264583] Voltage-gated calcium channel subunit beta3-2 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P54285-2 Cacnb3 (145111)
