Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8CC27-3 Cacnb2
| Class:Id | ReferenceIsoform:145103 |
|---|---|
| _chainChangeLog | chain:1-655 added on Fri February 6 2015 |
| _displayName | UniProt:Q8CC27-3 Cacnb2 |
| _timestamp | 2023-11-03 16:18:54 |
| chain | chain:1-655 |
| checksum | 77841E9C2613843D |
| comment | FUNCTION Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:14674701, PubMed:36424916). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity).SUBUNIT Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (By similarity). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity). Interacts with CACNA1C (By similarity). Interacts with RRAD; interaction may be involved in beta-adrenergic regulation of heart rate and contractile force (PubMed:36424916). Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane (By similarity). Interacts with TMIGD2 (By similarity). Interacts with CAMK2D (By similarity). Interacts with CBARP (PubMed:24751537). Interacts with CAMK2A (By similarity).SUBCELLULAR LOCATION Regulated through phosphorylation at Thr-549 by CaMK2D.SIMILARITY Belongs to the calcium channel beta subunit family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Voltage-dependent L-type calcium channel subunit beta-2 shortName: CAB2 alternativeName: Calcium channel voltage-dependent subunit beta 2 |
| geneName | Cacnb2 Cacnlb2 |
| identifier | Q8CC27 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Calcium channel Calcium transport Cell membrane Ion channel Ion transport Membrane Phosphoprotein Reference proteome SH3 domain Transport Voltage-gated channel |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Cacnb2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CACB2_MOUSE A2ASJ8 Q8C5J5 Q9CTQ6 |
| sequenceLength | 655 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | Q8CC27-3 |
| (referenceEntity) | [EntityWithAccessionedSequence:264589] Voltage-gated calcium channel subunit beta2-3 [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8CC27-3 Cacnb2 (145103)
