Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P55287-2 CDH11
| Class:Id | ReferenceIsoform:144894 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 6 2015;propeptide:23-53 added on Fri February 6 2015;chain:54-796 added on Fri February 6 2015 |
| _displayName | UniProt:P55287-2 CDH11 |
| _timestamp | 2024-11-03 20:18:11 |
| chain | signal peptide:1-22 propeptide:23-53 chain:54-796 |
| checksum | E17090EC95C59936 |
| comment | FUNCTION Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546).SUBUNIT Interacts with PCDH8.SUBCELLULAR LOCATION Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546).DOMAIN Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.DISEASE A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Cadherin-11 alternativeName: OSF-4 alternativeName: Osteoblast cadherin shortName: OB-cadherin |
| geneName | CDH11 |
| identifier | P55287 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Cell adhesion Cell membrane Chromosomal rearrangement Cleavage on pair of basic residues Deafness Disease variant Glycoprotein Intellectual disability Membrane Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDH11 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995877] ENSEMBL:ENSG00000140937 CDH11 [Homo sapiens] |
| secondaryIdentifier | CAD11_HUMAN A8K5D6 A8MZC8 B7WP28 Q15065 Q15066 Q9UQ93 Q9UQ94 |
| sequenceLength | 796 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P55287-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:9759514] CDH11v [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P55287-2 CDH11 (144894)
