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Details on Person UniProt:Q8WXE1 ATRIP
| Class:Id | ReferenceGeneProduct:144344 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-791 added on Fri February 6 2015;initiator methionine:1 removed on Wed November 4 2015;chain:2-791 removed on Wed November 4 2015;chain:1-791 added on Wed November 4 2015;chain:1-791 removed on Fri May 6 2016;initiator methionine:1 added on Fri May 6 2016;chain:2-791 added on Fri May 6 2016;initiator methionine:1 removed on Fri August 12 2016;chain:2-791 removed on Fri August 12 2016;chain:1-791 added on Fri August 12 2016 |
| _displayName | UniProt:Q8WXE1 ATRIP |
| _timestamp | 2024-11-03 19:50:03 |
| chain | chain:1-791 |
| checksum | 58981602F7961756 |
| comment | FUNCTION Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.SUBUNIT Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.INTERACTION Redistributes to discrete nuclear foci upon DNA damage.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.PTM Phosphorylated by ATR.SIMILARITY Belongs to the ATRIP family.CAUTION The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: ATR-interacting protein alternativeName: ATM and Rad3-related-interacting protein |
| geneName | ATRIP AGS1 |
| identifier | Q8WXE1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Coiled coil Direct protein sequencing DNA damage DNA repair Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ATRIP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000472] ENSEMBL:ENSG00000164053 ATRIP [Homo sapiens] |
| secondaryIdentifier | ATRIP_HUMAN A8K6A3 A8K714 B2RCE7 B4DU92 B5MEB7 Q69YK9 Q8NHQ2 Q8WUG7 Q96CL3 Q9HA30 |
| sequenceLength | 791 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144345] UniProt:Q8WXE1-2 ATRIP [Homo sapiens] [ReferenceIsoform:144346] UniProt:Q8WXE1-3 ATRIP [Homo sapiens] [ReferenceIsoform:412160] UniProt:Q8WXE1-1 ATRIP [Homo sapiens] [ReferenceIsoform:8976888] UniProt:Q8WXE1-5 ATRIP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:176231] ATRIP [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8WXE1 ATRIP (144344)
