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Details on Person UniProt:Q99996-6 AKAP9
| Class:Id | ReferenceIsoform:143960 |
|---|---|
| _chainChangeLog | chain:1-3911 added on Fri February 6 2015 |
| _displayName | UniProt:Q99996-6 AKAP9 |
| _timestamp | 2024-11-03 20:13:11 |
| chain | chain:1-3907 |
| checksum | 81761B4341430CDF |
| comment | FUNCTION Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697).FUNCTION Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.SUBUNIT Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1 (PubMed:15047863). Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5 (PubMed:12163479). CSNK1D binding promotes its centrosomal subcellular location (PubMed:12270714). Interacts with GM130/GOLGA2; leading to recruitment to the Golgi apparatus (PubMed:19242490). Interacts with KCNQ1; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1), to the heterodimer KCNQ1-KCNE1 (PubMed:11799244). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction stabilizes both proteins (PubMed:25217626, PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13, recruits CAMSAP2 to the Golgi apparatus (PubMed:27666745, PubMed:28814570). Forms a pericentrosomal complex with CDK5RAP2, EB1/MAPRE1 and PDE4DIP isoform 13; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (PubMed:29162697). Interacts with MAPRE1 and MAPRE3 (PubMed:28814570). Interacts (via C-terminus) with CAMSAP2; this interaction is much stronger in the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). Interacts with CAMSAP3 (PubMed:28089391). Interacts (via C-terminus) with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:27666745).INTERACTION Cytoplasmic in parietal cells (PubMed:9915845). Recruited to the Golgi apparatus by GM130/GOLGA2 (PubMed:25657325). Localization at the centrosome versus Golgi apparatus may be cell line-dependent. In SKBr3 and HEK293F cells, exclusively located at the centrosome (PubMed:29162697). In HeLa, MDA-MB231 and RPE-1 cells, detected at the Golgi apparatus (PubMed:25217626, PubMed:29162697). In SK-BR-3 cells, recruited to the centrosome in the presence of CDK5RAP2 (PubMed:29162697).ALTERNATIVE PRODUCTS Widely expressed (PubMed:10202149). Isoform 4: Highly expressed in skeletal muscle and in pancreas (PubMed:9482789).DOMAIN RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: A-kinase anchor protein 9 shortName: AKAP-9 alternativeName: A-kinase anchor protein 350 kDa shortName: AKAP 350 shortName: hgAKAP 350 alternativeName: A-kinase anchor protein 450 kDa shortName: AKAP 450 alternativeName: AKAP 120-like protein alternativeName: fullName evidence="23"Centrosome- and Golgi-localized PKN-associated protein shortName evidence="23"CG-NAP alternativeName: fullName evidence="25"Protein hyperion alternativeName: Protein kinase A-anchoring protein 9 shortName: PRKA9 alternativeName: fullName evidence="24"Protein yotiao |
| geneName | AKAP9 AKAP350 AKAP450 KIAA0803 |
| identifier | Q99996 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Golgi apparatus Long QT syndrome Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AKAP9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962267] ENSEMBL:ENSG00000127914 AKAP9 [Homo sapiens] |
| secondaryIdentifier | AKAP9_HUMAN A4D1F0 A4D1F2 A4D1F4 O14869 O43355 O94895 Q75N20 Q9UQH3 Q9UQQ4 Q9Y6B8 Q9Y6Y2 |
| sequenceLength | 3907 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q99996-6 |
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No pathways have been reviewed or authored by UniProt:Q99996-6 AKAP9 (143960)
