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Details on Person UniProt:O35889 Afdn
| Class:Id | ReferenceGeneProduct:143897 |
|---|---|
| _chainChangeLog | chain:1-1829 added on Sat February 7 2015 |
| _displayName | UniProt:O35889 Afdn |
| _timestamp | 2023-11-03 17:10:41 |
| chain | chain:1-1829 |
| checksum | 45C597A82F109D6F |
| comment | FUNCTION Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity).SUBUNIT Homodimer. Interacts with F-actin, nectin and NECTIN3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR (By similarity). Interacts with ADAM10; the interaction locks ADAM10 at adherens junctions following ADAM10 recruitment to adherens junctions by TSPAN33 (PubMed:30463011).INTERACTION Not found at cell-matrix AJs.ALTERNATIVE PRODUCTS Isoform 1 is widely expressed, including in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is mainly expressed in the brain.MISCELLANEOUS Isoform 1 increases the viscosity of F-actin in a dose-dependent manner. Isoform 1 causes F-actin to associate into bundles and meshworks. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Afadin alternativeName: fullName evidence="12"Afadin adherens junction formation factor alternativeName: Protein Af-6 |
| geneName | Afdn Af6 Mllt4 |
| identifier | O35889 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cell adhesion Cell junction Coiled coil Direct protein sequencing Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Afdn |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AFAD_RAT O35890 |
| sequenceLength | 1829 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:143898] UniProt:O35889-2 Afdn [Rattus norvegicus] [ReferenceIsoform:401437] UniProt:O35889-1 Afdn [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:433723] Afadin [cytosol] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:O35889 Afdn (143897)
