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Details on Person UniProt:P34969-2 HTR7
| Class:Id | ReferenceIsoform:143592 |
|---|---|
| _chainChangeLog | chain:1-479 added on Fri February 6 2015 |
| _displayName | UniProt:P34969-2 HTR7 |
| _timestamp | 2024-11-03 20:13:00 |
| chain | chain:1-479 |
| checksum | 1F62E985EADE1F23 |
| comment | FUNCTION G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614).INTERACTION Isoform A and isoform B appear to be expressed at higher levels.TISSUE SPECIFICITY Predominant isoform in spleen, caudate and hippocampus.TISSUE SPECIFICITY Expressed at lower levels.TISSUE SPECIFICITY Minor isoform in terms of expression.DOMAIN Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| description | recommendedName: fullName evidence="14"5-hydroxytryptamine receptor 7 shortName evidence="12"5-HT-7 shortName evidence="12"5-HT7 alternativeName: 5-HT-X alternativeName: fullName evidence="12"Serotonin receptor 7 |
| geneName | HTR7 |
| identifier | P34969 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HTR7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989941] ENSEMBL:ENSG00000148680 HTR7 [Homo sapiens] |
| secondaryIdentifier | 5HT7R_HUMAN B5BUP6 P78336 P78372 P78516 Q5VX01 Q5VX02 Q5VX03 |
| sequenceLength | 479 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P34969-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:9706412] HTR7 [trans-Golgi network membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P34969-2 HTR7 (143592)
