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Details on Person Synthesis of PIP3 from PIP2 by PI3K

Class:Id	Reaction:1433514
_displayName	Synthesis of PIP3 from PIP2 by PI3K
_doRelease	TRUE
_timestamp	2017-12-03 14:13:51
authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
catalystActivity	[CatalystActivity:1433507] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:202402] The role of PI3K in immune cells [LiteratureReference:1433467] Synthesis and function of 3-phosphorylated inositol lipids [LiteratureReference:1562567] Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
modified	[InstanceEdit:1500885] Garapati, P V, 2011-08-22 [InstanceEdit:1524178] Garapati, P V, 2011-08-24 [InstanceEdit:1538125] Garapati, P V, 2011-08-26 [InstanceEdit:1564913] Garapati, P V, 2011-09-05 [InstanceEdit:8940142] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:9031775] Orlic-Milacic, Marija, 2017-12-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Synthesis of PIP3 from PIP2 by PI3K
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:205262] Direct recruitment of PI3K to p-KIT [Homo sapiens] [Reaction:205289] Autophosphorylation of KIT [Homo sapiens] [Reaction:1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 [Homo sapiens] [BlackBoxEvent:1433454] Phosphorylation of GAB2 by SFKs [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591297] R-HSA-1433514.4
summation	[Summation:1433464] PI3 kinases catalyze the production of phosphatidylinositol-...
(hasEvent)	[Pathway:1433557] Signaling by SCF-KIT [Homo sapiens]
(normalReaction)	[Reaction:9670433] KIT mutants:PI3K catalyze synthesis of PIP3 [Homo sapiens]
(precedingEvent)	[Reaction:1433542] Phosphorylation and activation of VAV1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776954] Update Tracker - [Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K - v73:[modifyText] [_UpdateTracker:9777281] Update Tracker - [Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K - v72:[modifyText] [_UpdateTracker:9780126] Update Tracker - [Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K - v64:[addLiteratureReference] [_UpdateTracker:9782565] Update Tracker - [Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K - v59:[add_removeLiteratureReference]
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No pathways have been reviewed or authored by Synthesis of PIP3 from PIP2 by PI3K (1433514)