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Details on Person Phosphorylation of SHP2 by SFKs

Class:Id	Reaction:1433488
_displayName	Phosphorylation of SHP2 by SFKs
_doRelease	TRUE
_timestamp	2011-09-09 09:03:10
authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
catalystActivity	[CatalystActivity:1433495] protein tyrosine kinase activity of SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643977] protein tyrosine kinase activity of SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:205267] SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:205299] The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
modified	[InstanceEdit:1460241] Jupe, S, 2011-07-25 [InstanceEdit:1470007] Garapati, P V, 2011-08-01 [InstanceEdit:1500885] Garapati, P V, 2011-08-22 [InstanceEdit:1524178] Garapati, P V, 2011-08-24 [InstanceEdit:1538125] Garapati, P V, 2011-08-26 [InstanceEdit:1562643] Garapati, P V, 2011-09-05 [InstanceEdit:1564913] Garapati, P V, 2011-09-05 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SHP2 by SFKs
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:1433530] p-SHP2:p-KIT complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:205238] SHP2 interacts with p-KIT [Homo sapiens] [Reaction:205205] Interaction of Src family kinases with p-KIT [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591368] R-HSA-1433488.3
summation	[Summation:1433463] Following association with KIT, Tauchi et al. had observed p...
(hasEvent)	[Pathway:1433557] Signaling by SCF-KIT [Homo sapiens]
(precedingEvent)	[Reaction:1433428] GRB2 is indirectly recruited to p-KIT through SHP2 [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of SHP2 by SFKs (1433488)