Query author contributions in Reactome

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Details on Person Silke, J

Class:Id	Person:141939
_displayName	Silke, J
_timestamp	2004-10-04 17:57:42
firstname	John
initial	J
surname	Silke
(author)	[LiteratureReference:141217] HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. [LiteratureReference:5357863] Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction [LiteratureReference:5364089] The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism [LiteratureReference:5676481] TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha [LiteratureReference:5676516] TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis [LiteratureReference:5686140] Linear ubiquitination prevents inflammation and regulates immune signalling [LiteratureReference:5692339] Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor [LiteratureReference:9686453] Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [LiteratureReference:9686472] Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death [LiteratureReference:9686475] The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis List all 18 refering instances
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No pathways have been reviewed or authored by Silke, J (141939)