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Details on Person GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex

Class:Id	Reaction:141673
_displayName	GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
_doRelease	TRUE
_timestamp	2016-11-10 00:55:29
authored	[InstanceEdit:158455] Gillespie, ME, 2005-01-26 20:24:54
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:157572] Bedwell, D, 2005-01-03 15:16:42
figure	[Figure:141674] /figures/transterm_GTPhydrolysis.jpg
goBiologicalProcess	[GO_BiologicalProcess:18536] translational termination
inferredFrom	[Reaction:141687] GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex [Saccharomyces cerevisiae]
input	[Complex:143397] Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:143393] The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.
modified	[InstanceEdit:143402] Gillespie, ME, 2004-11-09 20:02:51 [InstanceEdit:143416] Gillespie, ME, 2004-11-09 20:40:47 [InstanceEdit:143520] Gillespie, ME, 2004-11-12 05:05:45 [InstanceEdit:156550] Gillespie, ME, 2004-11-20 14:13:10 [InstanceEdit:157364] Gillespie, ME, 2004-12-21 16:32:33 [InstanceEdit:157574] Joshi-Tope, G, 2005-01-03 20:16:54 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:169836] D'Eustachio, P, 2005-12-08 16:23:55 [InstanceEdit:188893] Gillespie, ME, 2006-10-28 18:41:35 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:6814562] Jassal, Bijay, 2015-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
output	[Complex:143381] Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:141691] GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex [Homo sapiens] [Reaction:156915] Translocation of ribosome by 3 bases in the 3' direction [Homo sapiens] [Reaction:6800138] N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359649] R-HSA-141673.4
summation	[Summation:157358] Please note that this reaction was inferred from experiments...
(hasEvent)	[Pathway:72764] Eukaryotic Translation Termination [Homo sapiens]
(inferredFrom)	[Reaction:1113127] GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex [Oryza sativa]
(orthologousEvent)	[Reaction:1113127] GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex [Oryza sativa]
(precedingEvent)	[Reaction:141671] Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783685] Update Tracker - [Reaction:141673] GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex - v56:[addInput]
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No pathways have been reviewed or authored by GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (141673)