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Details on Person Release of activated MAD2 from kinetochores

Class:Id	Reaction:141439
_displayName	Release of activated MAD2 from kinetochores
_doRelease	TRUE
_timestamp	2016-11-10 00:56:06
authored	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:143430] Yen, T, 2004-05-05 00:00:00
input	[Complex:141432] Kinetochore:Mad1:MAD2* Complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:143453] Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
modified	[InstanceEdit:141621] Matthews, L, 2004-09-24 02:07:16 [InstanceEdit:142067] Matthews, L, 2004-11-03 20:12:13 [InstanceEdit:143359] Matthews, L, 2004-11-09 14:12:28 [InstanceEdit:143435] Matthews, L, 2004-11-10 00:24:27 [InstanceEdit:143460] Matthews, L, 2004-11-10 00:53:46 [InstanceEdit:143461] Matthews, L, 2004-11-10 01:21:43 [InstanceEdit:143525] Schmidt, EE, 2004-11-12 05:53:46 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:177824] Matthews, L, 2006-04-10 08:37:24 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Release of activated MAD2 from kinetochores
output	[EntityWithAccessionedSequence:141447] Activated MAD2L1 [cytosol] [Homo sapiens] [Complex:141441] Mad1:kinetochore complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:141422] MAD2 converted to an inhibitory state via interaction with Mad1 [Homo sapiens] [Reaction:141431] MAD2 associates with the Mad1 kinetochore complex [Homo sapiens]
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359596] R-HSA-141439.3
summation	[Summation:143360] The mechanism by which the conformationally altered inhibito...
(hasEvent)	[Pathway:141444] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal [Homo sapiens]
(inferredFrom)	[Reaction:1113053] Release of activated MAD2 from kinetochores [Oryza sativa]
(orthologousEvent)	[Reaction:1113053] Release of activated MAD2 from kinetochores [Oryza sativa]
(precedingEvent)	[NegativePrecedingEvent:9749045] Incorrect Order: Release of activated MAD2 from kinetochores [Reaction:141429] Inactivation of APC/C via CDC20 sequestration [Homo sapiens] [Pathway:141430] Inactivation of APC/C via direct inhibition of the APC/C complex [Homo sapiens] [Reaction:141437] Formation of the MCC complex [Homo sapiens]
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No pathways have been reviewed or authored by Release of activated MAD2 from kinetochores (141439)