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Details on Person TRADD:TRAF2:RIP1 binds FADD

Class:IdReaction:140978
_displayNameTRADD:TRAF2:RIP1 binds FADD
_doReleaseTRUE
_timestamp2024-09-04 19:09:41
compartment[Compartment:70101] cytosol
created[InstanceEdit:110071] Tschopp, Jürg, 2004-01-28
edited[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
input[Complex:140935] TRAF2:TRADD:RIPK1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:54639] FADD [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:3465520] Shamovsky, V, 2013-05-17
[InstanceEdit:3597633] Shamovsky, V, 2013-05-22
[InstanceEdit:3632866] Shamovsky, V, 2013-05-28
[InstanceEdit:5658081] Shamovsky, V, 2014-12-17
[InstanceEdit:5676958] Shamovsky, Veronica, 2015-02-20
[InstanceEdit:5676973] Shamovsky, Veronica, 2015-02-20
[InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9819129] Shamovsky, Veronica, 2022-11-01
[InstanceEdit:9820614] Shamovsky, Veronica, 2022-11-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9920910] Shamovsky, Veronica, 2024-09-04
nameTRADD:TRAF2:RIP1 binds FADD
output[Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:5357864] Positive regulation by 'RIPK1 deubiquitinases [cytosol]'
[NegativeRegulation:9819130] Negative regulation by 'TRAF2:TRADD:p-S320-RIPK1 [cytosol]'
[NegativeRegulation:9819131] Negative regulation by 'TRAF2:TRADD:p-S357-RIPK1 [cytosol]'
releaseDate2004-10-27
reviewed[InstanceEdit:165094] Vaux, D, 0000-00-00 00:00:00
[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
[InstanceEdit:9818965] Tu, Hailin, 2022-10-31
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:3604387] Shamovsky, V, 2013-05-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358269] R-HSA-140978.7
summation[Summation:74353] Once formed in context of the TNFR1 signaling complex the TR...
(hasEvent)[Pathway:5357786] TNFR1-induced proapoptotic signaling [Homo sapiens]
(precedingEvent)[Reaction:75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 [Homo sapiens]
[Reaction:3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [Homo sapiens]
[BlackBoxEvent:5357828] RIPK1 is cleaved by CASP8 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784848] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v53:[modifyText]
[_UpdateTracker:9785516] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v52:[modifyText, removeRegulator]
[_UpdateTracker:9785794] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v51:[addRegulator]
[_UpdateTracker:9786039] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v50:[addRegulator]
[_UpdateTracker:9846921] Update Tracker - [Reaction:140978] TRADD:TRAF2:RIP1 complex binds FADD - v83:[addRegulator]
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No pathways have been reviewed or authored by TRADD:TRAF2:RIP1 binds FADD (140978)
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