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Details on Person TRADD:TRAF2:RIPK1:FADD [cytosol]

Class:IdComplex:140977
_displayNameTRADD:TRAF2:RIPK1:FADD [cytosol]
_timestamp2020-08-20 14:01:11
compartment[Compartment:70101] cytosol
created[InstanceEdit:140974] Gillespie, ME, 2004-08-25 17:28:36
goCellularComponent[GO_CellularComponent:161217] death-inducing signaling complex
hasComponent
literatureReference[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
[LiteratureReference:3465531] Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
modified[InstanceEdit:1606717] D'Eustachio, P, 2011-09-24
[InstanceEdit:3465514] Shamovsky, V, 2013-05-17
[InstanceEdit:3465534] Shamovsky, V, 2013-05-17
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9697738] Shamovsky, Veronica, 2020-08-20
[InstanceEdit:9715688] Shorser, Solomon, 2021-02-17
[InstanceEdit:9729976] Shorser, Solomon, 2021-05-05
[InstanceEdit:9750461] Weiser, JD, 2021-08-11
[InstanceEdit:9757984] Weiser, JD, 2021-11-08
[InstanceEdit:9767390] Wright, Adam, 2022-02-25
[InstanceEdit:9773515] Weiser, Joel, 2022-05-04
[InstanceEdit:9909910] Weiser, Joel, 2024-05-14
[InstanceEdit:9917728] Weiser, Joel, 2024-08-09
[InstanceEdit:9926726] Weiser, Joel, 2024-11-03
[InstanceEdit:9939161] Weiser, Joel, 2025-02-21
[InstanceEdit:9948552] Weiser, Joel, 2025-05-21
[InstanceEdit:9963749] Weiser, Joel, 2025-08-15
[InstanceEdit:9970792] Weiser, Joel, 2025-10-31
[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
[InstanceEdit:9989150] Weiser, Joel, 2026-05-15
nameTRADD:TRAF2:RIPK1:FADD
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:367733] R-HSA-140977.20
(hasComponent)[Complex:140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Homo sapiens]
[Complex:2671812] TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] [Homo sapiens]
[Complex:3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Homo sapiens]
[Complex:9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] [Homo sapiens]
(hasMember)[DefinedSet:2671814] DISC [plasma membrane] [Homo sapiens]
(input)[Reaction:75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 [Homo sapiens]
[Reaction:3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [Homo sapiens]
[BlackBoxEvent:5357828] RIPK1 is cleaved by CASP8 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:9693921] loss_of_function of TRADD:TRAF2:RIPK1 variant:FADD [cytosol]
(output)[Reaction:140978] TRADD:TRAF2:RIP1 binds FADD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9880091] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v44:[updateContainedComponent]
[_UpdateTracker:9884931] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v45:[addLiteratureReference, modifyName, updateContainedComponent]
[_UpdateTracker:9901588] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v74:[modifyName]
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No pathways have been reviewed or authored by TRADD:TRAF2:RIPK1:FADD [cytosol] (140977)
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