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Details on Person 12xCbxE-3D-F9(47-461) [extracellular region]
Class:Id EntityWithAccessionedSequence:140886
_displayName 12xCbxE-3D-F9(47-461) [extracellular region]
_timestamp 2016-03-17 22:34:28
compartment [Compartment:984] extracellular region
created [InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
endCoordinate 461
hasModifiedResidue [ModifiedResidue:140824] L-gamma-carboxyglutamic acid at 86 [ModifiedResidue:140835] L-gamma-carboxyglutamic acid at 82 [ModifiedResidue:140836] L-gamma-carboxyglutamic acid at 79 [ModifiedResidue:140878] L-gamma-carboxyglutamic acid at 76 [ModifiedResidue:140879] L-gamma-carboxyglutamic acid at 73 [ModifiedResidue:140880] L-gamma-carboxyglutamic acid at 72 [ModifiedResidue:140881] L-gamma-carboxyglutamic acid at 67 [ModifiedResidue:140882] L-gamma-carboxyglutamic acid at 66 [ModifiedResidue:140883] L-gamma-carboxyglutamic acid at 63 [ModifiedResidue:140884] L-gamma-carboxyglutamic acid at 61 [ModifiedResidue:140885] L-gamma-carboxyglutamic acid at 54 [ModifiedResidue:8865023] L-gamma-carboxyglutamic acid at 53 [ModifiedResidue:140818] (2S,3R)-3-hydroxyaspartic acid at 110
literatureReference [LiteratureReference:140887] Nucleotide sequence of the gene for human factor IX (antihemophilic factor B) [LiteratureReference:140890] The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens
modified [InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57 [InstanceEdit:163149] D'Eustachio, P, 2005-04-20 14:51:12 [InstanceEdit:3322333] Wu, G, 2013-05-03 [InstanceEdit:3322334] Wu, G, 2013-05-03 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:8865022] D'Eustachio, Peter, 2016-03-17
name 12xCbxE-3D-F9(47-461) 12xCbxE-3D-F9 factor IX
referenceEntity [ReferenceGeneProduct:54610] UniProt:P00740 F9 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:371477] R-HSA-140886.2
startCoordinate 47
(input) [Reaction:140823] OBSOLETE_factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)_REPLACEMENT_9929051_9929054 [Homo sapiens] [Reaction:158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) [Homo sapiens] [Reaction:9929051] TF:FVIIa+FIX -> TF:FVIIa:FIXa + FIX activation peptide (TF:F7a catalyst) [Homo sapiens] [Reaction:9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Homo sapiens]
(normalEntity) [EntityFunctionalStatus:9673206] loss_of_function of F9 zymogen variant [extracellular region]
(output) [BlackBoxEvent:9670673] FIX is secreted [Homo sapiens]
(updatedInstance) [_UpdateTracker:9885970] Update Tracker - [EntityWithAccessionedSequence:140886] 12xCbxE-3D-F9(47-461) [extracellular region] - v45:[addName] [_UpdateTracker:9894346] Update Tracker - [EntityWithAccessionedSequence:140886] 12xCbxE-3D-F9(47-461) [extracellular region] - v57:[addHasModifiedResidue, modifyName]
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No pathways have been reviewed or authored by 12xCbxE-3D-F9(47-461) [extracellular region] (140886)