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Details on Person thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs

Class:Id	Reaction:140872
_displayName	thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs
_doRelease	TRUE
_timestamp	2026-01-28 00:43:14
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:140871] thrombin:cleaved SERPINC1:HSPGs [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:140801] Heparin-induced substrate behavior of antithrombin Cambridge II
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9693042] Jassal, Bijay, 2020-06-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979586] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980377] Shamovsky, Veronica, 2026-01-27 [InstanceEdit:9980384] Shamovsky, Veronica, 2026-01-28
name	thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs
output	[Complex:140874] thrombin:cleaved SERPINC1 [extracellular region] [Homo sapiens] [DefinedSet:2076618] HSPGs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate [Homo sapiens] [Reaction:140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361274] R-HSA-140872.5
structureModified	[InstanceEdit:9979586] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980384] Shamovsky, Veronica, 2026-01-28
summation	[Summation:140873] The same conformational change that traps thrombin in its co...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776701] Update Tracker - [Reaction:140872] thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators - v74:[add_removeOutput] [_UpdateTracker:9984604] Update Tracker - [Reaction:140872] thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs - v96:[add_removeOutput]
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No pathways have been reviewed or authored by thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs (140872)