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Details on Person thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate

Class:Id	Reaction:140870
_displayName	thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate
_doRelease	TRUE
_timestamp	2026-01-27 19:13:27
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity	[CatalystActivity:140869] serine-type endopeptidase activity of thrombin:SERPINC1:HSPGs [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:140812] thrombin:SERPINC1:HSPGs [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:140801] Heparin-induced substrate behavior of antithrombin Cambridge II
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:190441] D'Eustachio, P, 2007-01-05 14:17:07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9980377] Shamovsky, Veronica, 2026-01-27
name	thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate
output	[Complex:140871] thrombin:cleaved SERPINC1:HSPGs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Homo sapiens] [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:9823290] SERPINC1 binds heparan sulfate [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358846] R-HSA-140870.4
summation	[Summation:140813] Antithrombin III in the complex is cleaved by thrombin, ther...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
(precedingEvent)	[Reaction:140872] thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792494] Update Tracker - [Reaction:140870] thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin - v20:[removeCatalystActivity]
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No pathways have been reviewed or authored by thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate (140870)