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Details on Person n fibrin monomers -> fibrin multimer

Class:Id	Reaction:140842
_displayName	n fibrin monomers -> fibrin multimer
_doRelease	TRUE
_timestamp	2024-11-20 00:24:50
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:140586] fibrin monomer [extracellular region] [Homo sapiens] [Complex:140586] fibrin monomer [extracellular region] [Homo sapiens] [Complex:140586] fibrin monomer [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140844] Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. [LiteratureReference:9929096] Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly
modified	[InstanceEdit:162932] D'Eustachio, P, 2005-04-10 20:56:31 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929119] Shamovsky, Veronica, 2024-11-20
name	n fibrin monomers -> fibrin multimer
output	[Complex:139933] fibrin multimer [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B [Homo sapiens] [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360553] R-HSA-140842.4
summation	[Summation:140843] Thrombin-mediated proteolytic cleavage in the central E doma...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769733] Fibrin formation [Homo sapiens]
(precedingEvent)	[Reaction:114560] Adhesion of integrin αIIbβ3 to fibrin network [Homo sapiens] [BlackBoxEvent:140851] fibrin multimer -> fibrin multimer, crosslinked + NH4+ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939841] Update Tracker - [Reaction:140842] n fibrin monomers -> fibrin multimer - v92:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by n fibrin monomers -> fibrin multimer (140842)