Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

Class:Id	Reaction:140840
_displayName	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
_doRelease	TRUE
_timestamp	2024-11-20 00:24:19
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
catalystActivityReference	[CatalystActivityReference:9929098] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region] Fibrinopeptides A and B release in the process of surface fibrin formation
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:114618] Fibrinogen [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140861] High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen [LiteratureReference:9929096] Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly [LiteratureReference:9929114] Fibrinopeptides A and B release in the process of surface fibrin formation
modified	[InstanceEdit:156791] D'Eustachio, P, 2004-12-10 22:20:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929113] Shamovsky, Veronica, 2024-11-20
name	fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
output	[Complex:140586] fibrin monomer [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140867] FGA(20-35) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140867] FGA(20-35) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140876] FGB(31-44) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140876] FGB(31-44) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens]
regulatedBy	[NegativeRegulation:5607099] Negative regulation by 'Extracellular thrombin inactivating complexes [extracellular region]' [NegativeRegulation:9015387] Negative regulation by 'Factor IIa inhibitors:IIa [extracellular region]'
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359398] R-HSA-140840.6
summation	[Summation:140860] Fibrinogen is a hexameric glycoprotein composed of two α (FG... [Summation:9603336] Some direct oral anticoagulant (DOAC) drugs are potent, comp...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769733] Fibrin formation [Homo sapiens]
(precedingEvent)	[Reaction:140842] n fibrin monomers -> fibrin multimer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776034] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v78:[addSummation] [_UpdateTracker:9779527] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v65:[addRegulator] [_UpdateTracker:9779760] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v64:[removeRegulator] [_UpdateTracker:9780362] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v63:[modifyText] [_UpdateTracker:9780542] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v62:[addRegulator, modifyText] [_UpdateTracker:9786192] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v50:[addRegulator] [_UpdateTracker:9939660] Update Tracker - [Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B - v92:[modifyText, removeLiteratureReference]
[Change default viewing format]

No pathways have been reviewed or authored by fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (140840)