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Details on Person activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate

Class:Id	Reaction:140791
_displayName	activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate
_doRelease	TRUE
_timestamp	2026-03-02 08:22:01
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
edited	[InstanceEdit:9979586] Shamovsky, Veronica, 2026-01-20
input	[Complex:156786] activated thrombin (factor IIa) [extracellular region] [Homo sapiens] [Complex:9823297] SERPINC1:HSPGs [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
literatureReference	[LiteratureReference:140801] Heparin-induced substrate behavior of antithrombin Cambridge II
modified	[InstanceEdit:156787] D'Eustachio, P, 2004-12-10 21:50:02 [InstanceEdit:156789] D'Eustachio, P, 2004-12-10 22:00:48 [InstanceEdit:158901] D'Eustachio, P, 2005-02-12 19:14:54 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:3150161] D'Eustachio, P, 2013-02-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979586] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980377] Shamovsky, Veronica, 2026-01-27 [InstanceEdit:9983932] Shamovsky, Veronica, 2026-03-02
name	activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate activated thrombin (factor IIa) + SERPINC1:HS -> thrombin:SERPINC1:HS
output	[Complex:140812] thrombin:SERPINC1:HSPGs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens] [Reaction:9823290] SERPINC1 binds heparan sulfate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:9934766] Shamovsky, Veronica, 2025-01-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361094] R-HSA-140791.4
structureModified	[InstanceEdit:9979586] Shamovsky, Veronica, 2026-01-20
summation	[Summation:140800] Activated thrombin binds to the antithrombin III:heparin com...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
(precedingEvent)	[Reaction:140870] thrombin:antithrombin III:heparan sulfate -> thrombin:cleaved antithrombin III:heparan sulfate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984573] Update Tracker - [Reaction:140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate - v96:[add_removeInput]
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No pathways have been reviewed or authored by activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate (140791)