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Details on Person OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)_REPLACEMENT_9822513_9929060_9922512

Class:Id	Reaction:140777
_displayName	OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)_REPLACEMENT_9822513_9929060_9922512
_doRelease	FALSE
_timestamp	2026-01-20 07:26:00
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity	[CatalystActivity:140776] serine-type endopeptidase activity of TF:F7 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:140739] factor X [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140743] Binding of human factor VII and VIIa to monocytes [LiteratureReference:140779] Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine [LiteratureReference:140782] Tissue factor and hemostasis
modified	[InstanceEdit:142087] Schmidt, EE, 2004-11-04 17:03:49 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979522] Shamovsky, Veronica, 2026-01-20
name	OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)_REPLACEMENT_9822513_9929060_9922512 activation of factor X by TF:F7
output	[Complex:140689] factor Xa [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140785] factor X activation peptide [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex [Homo sapiens] [Reaction:140761] sequestered tissue factor -> tissue factor [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360618] R-HSA-140777.3
summation	[Summation:140778] Factor VII, bound to tissue factor at the endothelial cell s...
(hasEvent)	[Pathway:140834] OBSOLETE_Extrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769735 [Homo sapiens] [Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:140769] factor VII -> factor VIIa [Homo sapiens]
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No pathways have been reviewed or authored by OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)_REPLACEMENT_9822513_9929060_9922512 (140777)