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Details on Person Coagulation factor VII (FVII) circulates in plasma mostly in...
| Class:Id | Summation:140772 |
|---|---|
| _displayName | Coagulation factor VII (FVII) circulates in plasma mostly in... |
| _timestamp | 2024-11-28 00:19:45 |
| created | [InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00 |
| literatureReference | [LiteratureReference:140782] Tissue factor and hemostasis [LiteratureReference:9671732] Activation of human factor VII in the initiation of tissue factor-dependent coagulation [LiteratureReference:9671738] Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation [LiteratureReference:9929035] A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates [LiteratureReference:9929040] Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients |
| modified | [InstanceEdit:9929038] Shamovsky, Veronica, 2024-11-20 [InstanceEdit:9929750] Shamovsky, Veronica, 2024-11-28 |
| text | Coagulation factor VII (FVII) circulates in plasma mostly in the zymogen form (Morrissey JH et al. 1993). During the initiation stage of coagulation, activated factor Xa (FXa) catalyzes the proteolytic activation of FVII from plasma (Rao LV et al. 1986; reviewed by Nemerson Y 1988). As factor VIIa accumulates, the formed TF:FVIIa complex accelerates the process of FXa generation through a reciprocal activation of FXa and FVIIa toward each other. A frequent human FVII A354V variant affects both activation of FVII by FXa and activation of FX by FVIIa (Toso R et al., 2002; Fromovich-Amit Y et al., 2004). This Reactome event shows cleavage of plasma zymogen FVII by soluble FXa between R212 and I213 in the region connecting the EGF2 and protease domains. This cleavage produces a two-chain FVIIa molecule, comprising FVII light chain (61-212) and FVII heavy chain (213-466), linked by disulfide bonds. |
| (summation) | [Reaction:140769] factor VII -> factor VIIa [Homo sapiens] |
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