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Details on Person factor VII -> factor VIIa

Class:Id	Reaction:140769
_displayName	factor VII -> factor VIIa
_doRelease	TRUE
_timestamp	2026-01-20 07:34:23
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity	[CatalystActivity:140768] serine-type endopeptidase activity of factor Xa [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:8959612] Factor VII:Ca2+ [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140773] Kinetics of human factor VII activation
modified	[InstanceEdit:142087] Schmidt, EE, 2004-11-04 17:03:49 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8959611] D'Eustachio, Peter, 2017-01-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979548] Shamovsky, Veronica, 2026-01-20
name	factor VII -> factor VIIa activation of factor VII
output	[Complex:140751] factor VIIa:Ca2+ [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens] [Reaction:140777] OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)_REPLACEMENT_9822513_9929060_9922512 [Homo sapiens] [Reaction:140783] tissue factor (TF) + factor VII (F7) -> TF:F7 complex [Homo sapiens] [Reaction:140736] OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)_REPLACEMENT_9822514 [Homo sapiens] [Reaction:140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360034] R-HSA-140769.5
summation	[Summation:140772] Coagulation factor VII (FVII) circulates in plasma mostly in...
(hasEvent)	[Pathway:140834] OBSOLETE_Extrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769735 [Homo sapiens] [Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781921] Update Tracker - [Reaction:140769] factor VII -> factor VIIa - v60:[add_removeInput] [_UpdateTracker:9939659] Update Tracker - [Reaction:140769] factor VII -> factor VIIa - v92:[modifyText]
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No pathways have been reviewed or authored by factor VII -> factor VIIa (140769)