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Details on Person prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

Class:IdReaction:140700
_displayNameprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
_doReleaseTRUE
_timestamp2026-01-20 07:41:58
authored[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity[CatalystActivity:140768] serine-type endopeptidase activity of factor Xa [extracellular region]
compartment[Compartment:984] extracellular region
created[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input[EntityWithAccessionedSequence:140674] 10xCbxE-F2(44-622) [extracellular region] [Homo sapiens]
literatureReference[LiteratureReference:140680] The factor V activation paradox
modified[InstanceEdit:156787] D'Eustachio, P, 2004-12-10 21:50:02
[InstanceEdit:156789] D'Eustachio, P, 2004-12-10 22:00:48
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9735231] Jassal, Bijay, 2021-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9979576] Shamovsky, Veronica, 2026-01-20
nameprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
output[Complex:156786] activated thrombin (factor IIa) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:140786] 10xCbxE-F2(44-327) [extracellular region] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9015052] Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]'
regulationReference[RegulationReference:9735230] Negative regulation by 'factor Xa:Factor Xa inhibitors [plasma membrane]' Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor
releaseDate2004-10-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359715] R-HSA-140700.6
summation[Summation:140701] Factor Xa catalyzes the activation of small amounts of throm...
(hasEvent)[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens]
[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)[Reaction:140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776067] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v78:[modifyText]
[_UpdateTracker:9779556] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v65:[addRegulator]
[_UpdateTracker:9779762] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v64:[removeRegulator]
[_UpdateTracker:9780359] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v63:[modifyText]
[_UpdateTracker:9780732] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v62:[addRegulator, modifyText]
[_UpdateTracker:9984649] Update Tracker - [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) - v96:[add_removeCatalystActivity, modifyText]
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