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Details on Person factor V -> factor Va + factor V activation peptide (thrombin catalyst)

Class:Id	Reaction:140696
_displayName	factor V -> factor Va + factor V activation peptide (thrombin catalyst)
_doRelease	TRUE
_timestamp	2025-01-13 18:10:38
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[EntityWithAccessionedSequence:140697] factor V [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140680] The factor V activation paradox
modified	[InstanceEdit:156791] D'Eustachio, P, 2004-12-10 22:20:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930891] Shamovsky, Veronica, 2024-12-06 [InstanceEdit:9935198] Shamovsky, Veronica, 2025-01-13
name	factor V -> factor Va + factor V activation peptide (thrombin catalyst)
output	[Complex:140692] factor Va [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140787] factor V activation peptide [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) [Homo sapiens] [Reaction:140736] OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)_REPLACEMENT_9822514 [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens] [Reaction:481007] Exocytosis of platelet alpha granule contents [Homo sapiens]
regulatedBy	[NegativeRegulation:5607095] Negative regulation by 'Extracellular thrombin inactivating complexes [extracellular region]' [NegativeRegulation:5607785] Negative regulation by 'SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane]'
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360430] R-HSA-140696.5
summation	[Summation:140698] This Reactome event describes thrombin (FIIa)-catalyzed clea...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786290] Update Tracker - [Reaction:140696] factor V -> factor Va + factor V activation peptide - v50:[addRegulator] [_UpdateTracker:9939719] Update Tracker - [Reaction:140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) - v92:[modifyText]
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No pathways have been reviewed or authored by factor V -> factor Va + factor V activation peptide (thrombin catalyst) (140696)