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Details on Person factor Va + factor Xa -> Va:Xa complex (prothrombinase)

Class:Id	Reaction:140686
_displayName	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
_doRelease	TRUE
_timestamp	2026-01-20 07:35:11
authored	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input	[Complex:140689] factor Xa [extracellular region] [Homo sapiens] [Complex:140692] factor Va [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:140650] Cofactor proteins in the assembly and expression of blood clotting enzyme complexes [LiteratureReference:9930537] Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding [LiteratureReference:9930565] Factor Va-factor Xa interactions: molecular sites involved in enzyme:cofactor assembly [LiteratureReference:9930542] Defining the factor Xa-binding site on factor Va by site-directed glycosylation [LiteratureReference:9930777] Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex [LiteratureReference:9930776] Cryo-EM structure of the prothrombin-prothrombinase complex [LiteratureReference:9930775] Cryo-EM structures of coagulation factors
modified	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930566] Shamovsky, Veronica, 2024-12-03 [InstanceEdit:9930808] Shamovsky, Veronica, 2024-12-06 [InstanceEdit:9938614] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9979551] Shamovsky, Veronica, 2026-01-20
name	factor Va + factor Xa -> Va:Xa complex (prothrombinase)
output	[Complex:140662] FVa:FXa [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9930792] factor Va intermediate -> factor Va [Homo sapiens] [Reaction:9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) [Homo sapiens] [Reaction:9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens] [Reaction:158164] factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) [Homo sapiens] [Reaction:158278] factor VIIIa + factor IXa -> factor VIIIa:factor IXa [Homo sapiens] [Reaction:140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) [Homo sapiens] [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) [Homo sapiens] [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:481007] Exocytosis of platelet alpha granule contents [Homo sapiens] [Reaction:140736] OBSOLETE_factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)_REPLACEMENT_9822514 [Homo sapiens] [Reaction:140748] tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex [Homo sapiens]
releaseDate	2004-10-27
requiredInputComponent	[SimpleEntity:74112] Ca2+ [extracellular region]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358903] R-HSA-140686.5
summation	[Summation:140693] In the presence of calcium ions (Ca²⁺), factor Va (FVa) and ...
(hasEvent)	[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens] [Pathway:9769735] Initiation of coagulation cascade [Homo sapiens] [Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846687] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v84:[modifyText] [_UpdateTracker:9939735] Update Tracker - [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) - v92:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by factor Va + factor Xa -> Va:Xa complex (prothrombinase) (140686)