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Details on Person prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

Class:IdReaction:140664
_displayNameprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
_doReleaseTRUE
_timestamp2024-12-06 09:36:00
authored[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
catalystActivity[CatalystActivity:140663] serine-type endopeptidase activity of FVa:FXa [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:140579] D'Eustachio, P, 2004-08-24 14:00:00
input[EntityWithAccessionedSequence:140674] 10xCbxE-F2(44-622) [extracellular region] [Homo sapiens]
literatureReference[LiteratureReference:140650] Cofactor proteins in the assembly and expression of blood clotting enzyme complexes
[LiteratureReference:140680] The factor V activation paradox
[LiteratureReference:9930777] Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex
[LiteratureReference:9930776] Cryo-EM structure of the prothrombin-prothrombinase complex
[LiteratureReference:9930775] Cryo-EM structures of coagulation factors
modified[InstanceEdit:141278] D'Eustachio, P, 2004-09-13 14:14:00
[InstanceEdit:141661] de Bono, B, 2004-09-27 14:03:17
[InstanceEdit:156787] D'Eustachio, P, 2004-12-10 21:50:02
[InstanceEdit:156789] D'Eustachio, P, 2004-12-10 22:00:48
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9930809] Shamovsky, Veronica, 2024-12-06
nameprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
FII -> FIIa + FII activation peptide (FVa:FXa catalyst)
output[Complex:156786] activated thrombin (factor IIa) [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:140786] 10xCbxE-F2(44-327) [extracellular region] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9015053] Negative regulation by 'Va:Xa:Factor Xa inhibitors [plasma membrane]'
releaseDate2004-10-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360877] R-HSA-140664.5
summation[Summation:140679] Factor Xa (FXa), a cleavage product of coagulation factor X ...
(hasEvent)[Pathway:140875] OBSOLETE_Common Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9769733 [Homo sapiens]
[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
[Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(precedingEvent)[Reaction:140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides [Homo sapiens]
[Reaction:140696] factor V -> factor Va + factor V activation peptide (thrombin catalyst) [Homo sapiens]
[Reaction:140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Homo sapiens]
[Reaction:140840] fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B [Homo sapiens]
[Reaction:141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin [Homo sapiens]
[Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer [Homo sapiens]
[Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) [Homo sapiens]
[FailedReaction:9666383] F8 variant is not cleaved by thrombin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775917] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v78:[modifyText]
[_UpdateTracker:9779537] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v65:[addRegulator]
[_UpdateTracker:9779960] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v64:[removeRegulator]
[_UpdateTracker:9780276] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v63:[modifyText]
[_UpdateTracker:9780724] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v62:[addRegulator, modifyText]
[_UpdateTracker:9939725] Update Tracker - [Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) - v92:[modifyText, removeLiteratureReference]
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