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Details on Person UniProt:P00742 F10
| Class:Id | ReferenceGeneProduct:140617 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Fri February 6 2015;propeptide:32-40 added on Fri February 6 2015;chain:41-488 added on Fri February 6 2015;chain:41-179 added on Fri February 6 2015;chain:183-488 added on Fri February 6 2015;propeptide:183-234 added on Fri February 6 2015;chain:235-488 added on Fri February 6 2015 |
| _displayName | UniProt:P00742 F10 |
| _timestamp | 2026-02-20 21:48:58 |
| chain | signal peptide:1-31 propeptide:32-40 chain:41-488 chain:41-179 chain:183-488 propeptide:183-234 chain:235-488 |
| checksum | F81D5746AF4797AF |
| comment | FUNCTION Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181, PubMed:18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner (PubMed:30568593, PubMed:34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Activates pro-inflammatory and pro-fibrotic responses in dermal fibroblasts and enhances wound healing probably via PAR-2/F2RL1-dependent mechanism (PubMed:18202198). Activates barrier protective signaling responses in endothelial cells in PAR-2/F2RL1-dependent manner; the activity depends on the cleavage of PAR-2/F2RL1 by factor Xa (PubMed:22409427). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed:24041930).CATALYTIC ACTIVITY Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.ACTIVITY REGULATION Inhibited by SERPINA5 and SERPINA10.SUBUNIT The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5. Interacts (inactive and activated) with ixolaris, an anticoagulant protein from Ixodes scapularis saliva (PubMed:11986214, PubMed:31133602, PubMed:18042685, PubMed:16807644). Interacts (activated) with iripin-8, a serine protease inhibitor from Ixodes ricinus saliva (PubMed:34502392). Interacts (activated) with FXa-directed anticoagulant from Aedes albopictus saliva (PubMed:21673107). Interacts (activated) with guianensin, an anticoagulant protein from Simulium guianense saliva (PubMed:37469515). Interacts (activated) with simukunin, an anticoagulant protein from Simulium vittatum saliva (PubMed:22383955).SUBUNIT (Microbial infection) Interacts (via Gla domain) with Human adenovirus C serotype 5 hexon protein; this interaction allows the virus to be shielded from its host immune system.INTERACTION Plasma; synthesized in the liver.PTM Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium.PTM N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.PTM Proteolytically cleaved and activated by cathepsin CTSG (PubMed:8920993). The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway) (By similarity).PTM The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family.ONLINE INFORMATION Factor X entry |
| description | recommendedName: Coagulation factor X ecNumber: 3.4.21.6 alternativeName: Stuart factor alternativeName: Stuart-Prower factor component recommendedName: Factor X light chain /component component recommendedName: Factor X heavy chain /component component recommendedName: Activated factor Xa heavy chain /component |
| geneName | F10 |
| identifier | P00742 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hemostasis Hydrolase Hydroxylation Protease Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | F10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994796] ENSEMBL:ENSG00000126218 F10 [Homo sapiens] |
| secondaryIdentifier | FA10_HUMAN Q14340 |
| sequenceLength | 488 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:140631] 11xCbxE-3D-F10(41-179) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140642] factor Xa heavy chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:140687] 11xCbxE-3D-F10(41-179) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140688] factor Xa heavy chain [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140738] factor X heavy chain [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140785] factor X activation peptide [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:159718] 11xCbxE-3D-F10(41-179) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:159774] 11xCbxE-3D-F10(32-179) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:159776] factor X heavy chain [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:159786] 11xCbxE-3D-F10(32-179) [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:140619] L-gamma-carboxyglutamic acid at 79 [ModifiedResidue:140620] L-gamma-carboxyglutamic acid at 72 [ModifiedResidue:140621] L-gamma-carboxyglutamic acid at 69 [ModifiedResidue:140622] L-gamma-carboxyglutamic acid at 66 [ModifiedResidue:140623] L-gamma-carboxyglutamic acid at 65 [ModifiedResidue:140624] L-gamma-carboxyglutamic acid at 60 [ModifiedResidue:140625] L-gamma-carboxyglutamic acid at 59 [ModifiedResidue:140626] L-gamma-carboxyglutamic acid at 56 [ModifiedResidue:140627] L-gamma-carboxyglutamic acid at 54 [ModifiedResidue:140628] L-gamma-carboxyglutamic acid at 47 |
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No pathways have been reviewed or authored by UniProt:P00742 F10 (140617)
