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Details on Person Transactivation of PMAIP1 (NOXA) by E2F1

Class:Id	BlackBoxEvent:140217
_displayName	Transactivation of PMAIP1 (NOXA) by E2F1
_doRelease	TRUE
_timestamp	2016-11-10 00:54:43
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
input	[EntityWithAccessionedSequence:4331342] PMAIP1 Gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:141113] Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
modified	[InstanceEdit:140521] Gopinathrao, G, 2004-08-19 14:26:21 [InstanceEdit:141111] Gopinathrao, G, 2004-08-31 15:42:16 [InstanceEdit:141115] Gopinathrao, G, 2004-08-31 17:54:38 [InstanceEdit:141255] Gopinathrao, G, 2004-09-07 18:44:40 [InstanceEdit:159037] Gopinathrao, G, 2005-02-16 19:58:30 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:4331346] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:8944143] Orlic-Milacic, Marija, 2016-11-03 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transactivation of PMAIP1 (NOXA) by E2F1
output	[EntityWithAccessionedSequence:140215] PMAIP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:4331327] E2F1 binds PMAIP1 (NOXA) promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:159039] Positive gene expression regulation by 'E2F1:TFDP1:PMAIP1 Gene [nucleoplasm]'
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361136] R-HSA-140217.4
summation	[Summation:179352] E2F1 directly stimulates the transcription of PMAIP1 (NOXA) ...
(hasEvent)	[Pathway:111448] Activation of NOXA and translocation to mitochondria [Homo sapiens]
(precedingEvent)	[Reaction:140216] Translocation of PMAIP1 (NOXA) to mitochondria [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787214] Update Tracker - [BlackBoxEvent:140217] Transactivation of PMAIP1 (NOXA) by E2F1 - v46:[addInput, add_removeRegulator] [_UpdateTracker:9787854] Update Tracker - [BlackBoxEvent:140217] Transactivation of PMAIP1 (NOXA) by E2F1 - v44:[modifyText]
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