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Details on Person Translocation of PMAIP1 (NOXA) to mitochondria

Class:Id	Reaction:140216
_displayName	Translocation of PMAIP1 (NOXA) to mitochondria
_doRelease	TRUE
_timestamp	2024-02-27 17:46:31
authored	[InstanceEdit:140377] Gopinathrao, G, 2004-08-18 11:49:08
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
goBiologicalProcess	[GO_BiologicalProcess:161847] protein insertion into mitochondrial membrane
input	[EntityWithAccessionedSequence:140215] PMAIP1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
modified	[InstanceEdit:140377] Gopinathrao, G, 2004-08-18 11:49:08 [InstanceEdit:141115] Gopinathrao, G, 2004-08-31 17:54:38 [InstanceEdit:141727] Gopinathrao, G, 2004-10-01 18:23:59 [InstanceEdit:143525] Schmidt, EE, 2004-11-12 05:53:46 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:3145023] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:4331346] Orlic-Milacic, M, 2013-08-16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863151] D'Eustachio, Peter, 2024-02-27
name	Translocation of PMAIP1 (NOXA) to mitochondria
output	[EntityWithAccessionedSequence:140218] PMAIP1 [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:140214] TP53 stimulates PMAIP1 (NOXA) expression [Homo sapiens] [Reaction:4331331] TP53 binds the PMAIP1 (NOXA) promoter [Homo sapiens] [BlackBoxEvent:140217] Transactivation of PMAIP1 (NOXA) by E2F1 [Homo sapiens] [Reaction:4331327] E2F1 binds PMAIP1 (NOXA) promoter [Homo sapiens]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360373] R-HSA-140216.4
summation	[Summation:140386] It was observed that cytosolic Noxa underwent BH3 motif-depe...
(hasEvent)	[Pathway:111448] Activation of NOXA and translocation to mitochondria [Homo sapiens]
(precedingEvent)	[Reaction:508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Homo sapiens] [Reaction:508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788010] Update Tracker - [Reaction:140216] Translocation of PMAIP1 (NOXA) to mitochondria - v44:[addLiteratureReference]
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