Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person FMO3:FAD N-oxidises TMA to TMAO

Class:IdReaction:139970
_displayNameFMO3:FAD N-oxidises TMA to TMAO
_doReleaseTRUE
_timestamp2015-10-23 14:03:23
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:114712] N,N-dimethylaniline monooxygenase activity of FMO3:FAD [endoplasmic reticulum membrane]
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:139962] Jassal, B, 2004-08-11 05:47:32
edited[InstanceEdit:350189] Jassal, B, 2008-05-14 09:43:11
input[SimpleEntity:30373] TMA [endoplasmic reticulum lumen]
[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:139971] Trimethylamine N-oxide synthesis: a human variant
[LiteratureReference:139976] Trimethylaminuria: the fish-odour syndrome
[LiteratureReference:5602993] Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication
[LiteratureReference:6806557] Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
modified[InstanceEdit:140961] Jassal, B, 2004-08-25 10:59:57
[InstanceEdit:141702] Jassal, B, 2004-09-30 09:25:15
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:217275] Jassal, B, 2008-03-26 09:20:04
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351778] Jassal, Bijay, 2008-05-28
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:389952] Jassal, Bijay, 2009-01-21
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602968] Jassal, Bijay, 2014-06-25
[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
[InstanceEdit:6806548] Jassal, Bijay, 2015-10-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFMO3:FAD N-oxidises TMA to TMAO
Trimethylamine N-oxidised to Trimethylamine-N-oxide
output[SimpleEntity:140963] TMAO [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358546] R-HSA-139970.3
summation[Summation:179274] Trimethylamine (TMA) is present in the diet (in fish) but pr...
(hasEvent)[Pathway:217271] FMO oxidises nucleophiles [Homo sapiens]
(normalReaction)[FailedReaction:5602966] Defective FMO3 does not N-oxidise TMA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783978] Update Tracker - [Reaction:139970] FMO3:FAD N-oxidises TMA to TMAO - v55:[addLiteratureReference, modifyText]
[_UpdateTracker:9786333] Update Tracker - [Reaction:139970] FMO3:FAD N-oxidises TMA to TMAO - v50:[addLiteratureReference, modifyText]
[_UpdateTracker:9789743] Update Tracker - [Reaction:139970] FMO3:FAD N-oxidises TMA to TMAO - v37:[modifyText]
[_UpdateTracker:9791604] Update Tracker - [Reaction:139970] FMO3:FAD N-oxidises TMA to TMAO - v28:[addInput]
[_UpdateTracker:9791820] Update Tracker - [Reaction:139970] FMO3:FAD N-oxidises TMA to TMAO - v25:[modifyText, removeInput]
[Change default viewing format]
No pathways have been reviewed or authored by FMO3:FAD N-oxidises TMA to TMAO (139970)