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Details on Person Once recruited to the activated receptor, PI3K phosphorylate...

Class:IdSummation:1384553
_displayNameOnce recruited to the activated receptor, PI3K phosphorylate...
_timestamp2012-02-05 02:19:40
created[InstanceEdit:1384552] Rothfels, K, 2011-07-06
modified[InstanceEdit:2085600] Rothfels, K, 2012-02-03
[InstanceEdit:2085645] Rothfels, K, 2012-02-05
textOnce recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).
(summation)[Reaction:1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
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