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Details on Person Expression of SREBF1 (SREBP1)

Class:Id	BlackBoxEvent:1368081
_displayName	Expression of SREBF1 (SREBP1)
_doRelease	TRUE
_timestamp	2025-02-18 21:03:25
authored	[InstanceEdit:1368114] May, B, 2011-06-22
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1368132] May, B, 2011-06-29
edited	[InstanceEdit:1368114] May, B, 2011-06-22
inferredFrom	[BlackBoxEvent:1368139] Expression of Srebf1 [Mus musculus]
input	[EntityWithAccessionedSequence:5641206] SREBF1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1368918] SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene [LiteratureReference:1368888] SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis [LiteratureReference:1368887] Sterol mediated regulation of SREBP-1a,1b,1c and SREBP-2 in cultured human cells [LiteratureReference:1368926] Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
modified	[InstanceEdit:1368177] May, B, 2011-06-29 [InstanceEdit:1368921] May, B, 2011-06-30 [InstanceEdit:1801592] May, B, 2011-10-24 [InstanceEdit:2084234] May, B, 2012-01-30 [InstanceEdit:2153491] May, B, 2012-02-28 [InstanceEdit:5641233] May, Bruce, 2014-11-16 [InstanceEdit:5663298] May, Bruce, 2015-01-17 [InstanceEdit:9036879] May, Bruce, 2018-02-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627003] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9697139] May, Bruce, 2020-08-06 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9934287] May, Bruce, 2025-01-07 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Expression of SREBF1 (SREBP1)
output	[EntityWithAccessionedSequence:1368141] SREBF1(1-1147) [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:5663293] RORA and EP300 bind the SREBF1 (SREBP1) gene [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:1368163] Positive gene expression regulation by 'RORA:EP300:SREBF1 gene [nucleoplasm]'
releaseDate	2012-03-13
reviewed	[InstanceEdit:2084235] Delaunay, F, 2012-01-28 [InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158164] R-HSA-1368081.9
summation	[Summation:1368097] The SREBF1 (SREBP1) gene is transcribed to yield mRNA and th...
(hasEvent)	[Pathway:9933387] RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775808] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v78:[addSummation] [_UpdateTracker:9779565] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v65:[removeRegulator] [_UpdateTracker:9780083] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v64:[addRegulator] [_UpdateTracker:9785275] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v52:[add_removeRegulator] [_UpdateTracker:9785866] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v51:[addInput] [_UpdateTracker:9939630] Update Tracker - [BlackBoxEvent:1368081] Expression of SREBF1 (SREBP1) - v92:[addSummation, modifyText]
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No pathways have been reviewed or authored by Expression of SREBF1 (SREBP1) (1368081)