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Details on Person NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm]

Class:Id	Complex:1368079
_displayName	NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm]
_timestamp	2015-01-16 22:32:47
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1368132] May, B, 2011-06-29
hasComponent	[Complex:1368127] NR1D1 (REV-ERBA):heme [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:375499] NR1D1 [nucleoplasm] [Homo sapiens] [SimpleEntity:1368125] ferriheme b [nucleoplasm] [EntityWithAccessionedSequence:442464] HDAC3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:442501] NCOR1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1368067] Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction [LiteratureReference:549400] The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene [LiteratureReference:1368128] Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways [LiteratureReference:549530] Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
modified	[InstanceEdit:1368177] May, B, 2011-06-29 [InstanceEdit:1478317] May, B, 2011-08-10 [InstanceEdit:1478320] May, B, 2011-08-10 [InstanceEdit:5663276] May, Bruce, 2015-01-16
name	NR1D1 (REV-ERBA):heme:Corepressor
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591657] R-HSA-1368079.1
(hasComponent)	[Complex:5663248] NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm] [Homo sapiens] [Complex:5663261] NR1D1:heme:Corepressors:ELOVL3 gene [nucleoplasm] [Homo sapiens] [Complex:5663262] NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm] [Homo sapiens] [Complex:5663269] NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm] [Homo sapiens] [Complex:5663272] NR1D1:heme:Corepressors:PPARGC1A gene [nucleoplasm] [Homo sapiens] [Complex:5663274] NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm] [Homo sapiens]
(regulator)	[NegativeGeneExpressionRegulation:1368168] Negative gene expression regulation by 'NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9891477] Update Tracker - [Complex:1368079] NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm] - v52:[addLiteratureReference, removeHasComponent]
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No pathways have been reviewed or authored by NR1D1 (REV-ERBA):heme:Corepressor [nucleoplasm] (1368079)