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Details on Person NR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors

Class:IdReaction:1368069
_displayNameNR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors
_doReleaseTRUE
_timestamp2025-02-18 21:05:06
authored[InstanceEdit:1368114] May, B, 2011-06-22
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:1368132] May, B, 2011-06-29
edited[InstanceEdit:1368114] May, B, 2011-06-22
input[EntityWithAccessionedSequence:5640173] ARNTL gene [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:442464] HDAC3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:442501] NCOR1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:375499] NR1D1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:1368125] ferriheme b [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:549530] Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
[LiteratureReference:1368067] Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction
[LiteratureReference:549400] The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene
[LiteratureReference:1368128] Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
modified[InstanceEdit:1368177] May, B, 2011-06-29
[InstanceEdit:2084234] May, B, 2012-01-30
[InstanceEdit:2153491] May, B, 2012-02-28
[InstanceEdit:5252142] May, B, 2014-02-05
[InstanceEdit:5663276] May, Bruce, 2015-01-16
[InstanceEdit:5663310] May, Bruce, 2015-01-17
[InstanceEdit:5667134] May, Bruce, 2015-01-23
[InstanceEdit:9697139] May, Bruce, 2020-08-06
[InstanceEdit:9713328] Stephan, Ralf, 2021-01-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
[InstanceEdit:9936592] May, Bruce, 2025-01-24
[InstanceEdit:9936865] May, Bruce, 2025-01-27
[InstanceEdit:9938391] May, Bruce, 2025-02-14
[InstanceEdit:9938697] May, Bruce, 2025-02-18
nameNR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors
output[Complex:5663269] NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2012-03-13
reviewed[InstanceEdit:2084235] Delaunay, F, 2012-01-28
[InstanceEdit:9713327] Somers, Julia, 2021-01-23
[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2158196] R-HSA-1368069.6
summation[Summation:1368126] NR1D1 (REV-ERBA) binds heme (Raghuram et al. 2007). The NR1D...
(hasEvent)[Pathway:9707616] Heme signaling [Homo sapiens]
[Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens]
(replacementInstances)[_Deleted:9032440] Deletion of instance: 5334727
(updatedInstance)[_UpdateTracker:9785163] Update Tracker - [Reaction:1368069] NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. - v52:[add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9939715] Update Tracker - [Reaction:1368069] NR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors - v92:[modifyText]
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