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Details on Person The NPAS2 gene is transcribed to yield mRNA and the mRNA is ...
| Class:Id | Summation:1368066 |
|---|---|
| _displayName | The NPAS2 gene is transcribed to yield mRNA and the mRNA is ... |
| _timestamp | 2025-01-12 21:04:12 |
| created | [InstanceEdit:1368132] May, B, 2011-06-29 |
| modified | [InstanceEdit:1368177] May, B, 2011-06-29 [InstanceEdit:9711048] Stephan, Ralf, 2021-01-11 [InstanceEdit:9717154] May, Bruce, 2021-03-04 [InstanceEdit:9935064] May, Bruce, 2025-01-12 |
| text | The NPAS2 gene is transcribed to yield mRNA and the mRNA is transcribed to yield NPAS2 protein (Zhou et al. 1997, Matsumura et al. 2013, also inferred from mouse homologs). Transcription of NPAS2 is enhanced by the RORA:coactivator complex and repressed by the NR1D1:corepressor complex (REV-ERBA:corepressor complex). ROR-alpha (RORA) binds the promoter of the NPAS2 gene and enhances transcription (Matsumura et al. 2013, and inferred from mouse homologs). RORA binds ROR response elements (RRE, RORE) and recruits the coactivators PGC-1alpha (PPARGC1A) and p300 (EP300, a histone acetylase) (inferred from mouse homologs). |
| (summation) | [BlackBoxEvent:1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 [Homo sapiens] |
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No pathways have been reviewed or authored by The NPAS2 gene is transcribed to yield mRNA and the mRNA is ... (1368066)
