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Details on Person RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2
Class:Id BlackBoxEvent:1368065 _displayName RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 _doRelease TRUE _timestamp 2025-07-21 16:38:07 authored [InstanceEdit:1368114] May, B, 2011-06-22 compartment [Compartment:7660] nucleoplasm [Compartment:70101] cytosol created [InstanceEdit:1368132] May, B, 2011-06-29 edited [InstanceEdit:1368114] May, B, 2011-06-22 goBiologicalProcess [GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II inferredFrom
input [EntityWithAccessionedSequence:5640176] NPAS2 gene [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:1368907] Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system [LiteratureReference:5669329] Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2) modified [InstanceEdit:1368177] May, B, 2011-06-29 [InstanceEdit:1368921] May, B, 2011-06-30 [InstanceEdit:1801593] May, B, 2011-10-24 [InstanceEdit:1989744] May, B, 2011-11-13 [InstanceEdit:2084234] May, B, 2012-01-30 [InstanceEdit:5640212] May, Bruce, 2014-11-16 [InstanceEdit:5663276] May, Bruce, 2015-01-16 [InstanceEdit:5669335] May, Bruce, 2015-02-02 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626999] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9697139] May, Bruce, 2020-08-06 [InstanceEdit:9707568] Stephan, Ralf, 2020-11-19 [InstanceEdit:9713328] Stephan, Ralf, 2021-01-25 [InstanceEdit:9717154] May, Bruce, 2021-03-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21 name RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 output [EntityWithAccessionedSequence:400314] NPAS2 [cytosol] [Homo sapiens] precedingEvent
regulatedBy [NegativeGeneExpressionRegulation:1368161] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1368165] Positive gene expression regulation by 'RORA:EP300:NPAS2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1989795] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' regulationReference [RegulationReference:9642459] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]' Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene [RegulationReference:9642726] Positive gene expression regulation by 'RORA:EP300:NPAS2 gene [nucleoplasm]' Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene [RegulationReference:9642870] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human releaseDate 2011-12-06 reviewed [InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:2084235] Delaunay, F, 2012-01-28 [InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2016678] R-HSA-1368065.11 summation [Summation:1368066] The NPAS2 gene is transcribed to yield mRNA and the mRNA is ... (hasEvent) [Pathway:1989781] PPARA activates gene expression [Homo sapiens] [Pathway:9707616] Heme signaling [Homo sapiens] [Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens] (updatedInstance) [_UpdateTracker:9775732] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v78:[addSummation] [_UpdateTracker:9776189] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v77:[modifyText] [_UpdateTracker:9776378] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v76:[modifyText] [_UpdateTracker:9785520] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v52:[addLiteratureReference, add_removeRegulator] [_UpdateTracker:9785727] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v51:[addInput] [_UpdateTracker:9788747] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v40:[add_removeRegulator] [_UpdateTracker:9939733] Update Tracker - [BlackBoxEvent:1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 - v92:[addSummation, modifyText]
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No pathways have been reviewed or authored by RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 (1368065)
