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Details on Person The model for PRL-induced PRLR activation suggests that JAK2...
| Class:Id | Summation:1364074 |
|---|---|
| _displayName | The model for PRL-induced PRLR activation suggests that JAK2... |
| _timestamp | 2011-11-08 17:15:26 |
| created | [InstanceEdit:1364048] Jupe, S, 2011-06-23 |
| literatureReference | [LiteratureReference:1368965] A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription [LiteratureReference:1302679] Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5 |
| modified | [InstanceEdit:1368966] Jupe, S, 2011-07-01 [InstanceEdit:1434478] Jupe, S, 2011-07-12 [InstanceEdit:1671654] Jupe, S, 2011-10-17 [InstanceEdit:1979908] Jupe, S, 2011-11-08 |
| text | The model for PRL-induced PRLR activation suggests that JAK2 phosphorylates PRLR on specific tyrosine residues. Consistent with this, JAK2 and PRLR are phosphorylated in response to activating ligand (Lebrun et al. 1994) and PRLR tyrosine phosphorylation is required for subsequent Stat signaling (Pezet et al. 1997). Though this evidence is consistent with a role for JAK2, it has not been formally demonstrated that JAK2 is the kinase responsible for PRLR tyrosine phosphorylation. |
| (summation) | [BlackBoxEvent:1364043] Tyrosine phosphorylation of PRLR [Homo sapiens] |
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No pathways have been reviewed or authored by The model for PRL-induced PRLR activation suggests that JAK2... (1364074)
