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Details on Person Ubiquitination of p130 (RBL2) by SCF (Skp2)

Class:Id	Reaction:1363331
_displayName	Ubiquitination of p130 (RBL2) by SCF (Skp2)
_doRelease	TRUE
_timestamp	2022-02-08 21:28:39
authored	[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
catalystActivity	[CatalystActivity:1363330] ubiquitin-protein transferase activity of p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
input	[Complex:1363326] p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1363319] The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)
modified	[InstanceEdit:1363603] Orlic-Milacic, Marija, 2011-06-15 [InstanceEdit:1493105] Orlic-Milacic, Marija, 2011-08-15 [InstanceEdit:1538155] Orlic-Milacic, Marija, 2011-08-26 [InstanceEdit:1538173] Orlic-Milacic, Marija, 2011-08-26 [InstanceEdit:1579360] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:9764006] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitination of p130 (RBL2) by SCF (Skp2)
negativePrecedingEvent	[NegativePrecedingEvent:9763998] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
output	[Complex:187547] CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [Homo sapiens] [Complex:1363324] Ub-p-T401,S672,1035-RBL2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:1363328] Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex [Homo sapiens] [Reaction:1226094] Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex [Homo sapiens] [Reaction:187545] Association of Cks1 with SCF(Skp2) complex [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1538129] MacPherson, D, 2011-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591305] R-HSA-1363331.3
summation	[Summation:1363322] As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is...
(hasEvent)	[Pathway:69231] Cyclin D associated events in G1 [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764002] Futile Cycle: Ubiquitination of p130 (RBL2) by SCF (Skp2) [NegativePrecedingEvent:9764004] Futile Cycle: Ubiquitination of p130 (RBL2) by SCF (Skp2)
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