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Details on Person Frataxin binds iron

Class:IdReaction:1362416
_displayNameFrataxin binds iron
_doReleaseTRUE
_timestamp2025-06-16 12:39:10
authored[InstanceEdit:2473458] Lill, R, 2012-09-24
[InstanceEdit:1362415] May, B, 2011-06-04
catalystActivity[CatalystActivity:9954151] ferrous iron binding activity of FXN:ISD11:NFS1:ISCU [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:1362407] May, B, 2011-06-09
edited[InstanceEdit:1362415] May, B, 2011-06-04
input[Complex:1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113531] Fe2+ [mitochondrial matrix]
[SimpleEntity:113531] Fe2+ [mitochondrial matrix]
[SimpleEntity:113531] Fe2+ [mitochondrial matrix]
[SimpleEntity:113531] Fe2+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06
isChimericFALSE
literatureReference[LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex
[LiteratureReference:1362328] Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex
[LiteratureReference:1362331] Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins
[LiteratureReference:1362373] Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein
[LiteratureReference:1362380] Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia
[LiteratureReference:2466328] Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex
[LiteratureReference:2466325] Iron-sulfur protein maturation in human cells: evidence for a function of frataxin
[LiteratureReference:1481605] Frataxin and mitochondrial FeS cluster biogenesis
modified[InstanceEdit:2395513] May, B, 2012-07-02
[InstanceEdit:2426693] May, B, 2012-08-08
[InstanceEdit:2463806] May, B, 2012-08-30
[InstanceEdit:2466333] May, B, 2012-09-06
[InstanceEdit:2473460] May, B, 2012-09-24
[InstanceEdit:2520970] May, B, 2012-10-11
[InstanceEdit:2559593] May, B, 2012-11-02
[InstanceEdit:5255114] May, B, 2014-02-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9954149] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9954172] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9956891] D'Eustachio, Peter, 2025-06-16
nameFrataxin binds iron
output[Complex:1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2012-12-04
reviewed[InstanceEdit:2520930] Rouault, Tracey A, 2012-10-11
[InstanceEdit:2520940] Tong, Wing-Hang, 2012-10-11
[InstanceEdit:9956890] Hill, David P, 2025-06-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200498] R-HSA-1362416.3
structureModified[InstanceEdit:9954149] D'Eustachio, Peter, 2025-06-06
summation[Summation:1362311] Frataxin (FXN) specifically binds 2 atoms of ferrous iron pe...
(hasEvent)[Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964752] Update Tracker - [Reaction:1362416] Frataxin binds iron - v94:[removeCatalystActivity]
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No pathways have been reviewed or authored by Frataxin binds iron (1362416)
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