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Details on Person FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster

Class:Id	BlackBoxEvent:1362408
_displayName	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster
_doRelease	TRUE
_timestamp	2020-02-10 02:19:15
authored	[InstanceEdit:2473458] Lill, R, 2012-09-24 [InstanceEdit:1362415] May, B, 2011-06-04
catalystActivity	[CatalystActivity:1362414] cysteine desulfurase activity of 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643875] cysteine desulfurase activity of 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1362407] May, B, 2011-06-09
edited	[InstanceEdit:1362415] May, B, 2011-06-04
input	[Complex:1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] [Homo sapiens] [SimpleEntity:379721] L-Cys [mitochondrial matrix] [SimpleEntity:379721] L-Cys [mitochondrial matrix] [SimpleEntity:379721] L-Cys [mitochondrial matrix] [SimpleEntity:379721] L-Cys [mitochondrial matrix] [DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex [LiteratureReference:1362362] Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis [LiteratureReference:1362327] Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones [LiteratureReference:1362331] Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins [LiteratureReference:2395493] Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis [LiteratureReference:2395461] Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis [LiteratureReference:2466324] Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation [LiteratureReference:2466309] An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1 [LiteratureReference:2466297] (IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer [LiteratureReference:2466306] Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p [LiteratureReference:2466277] Structure, function, and formation of biological iron-sulfur clusters [LiteratureReference:2466296] NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein [LiteratureReference:2466343] A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins [LiteratureReference:2520935] A proposed role for the Azotobacter vinelandii NfuA protein as an intermediate iron-sulfur cluster carrier [LiteratureReference:2520943] Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster [LiteratureReference:2520962] Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes [LiteratureReference:2520948] Interaction of J-protein co-chaperone Jac1 with Fe-S scaffold Isu is indispensable in vivo and conserved in evolution [LiteratureReference:2520964] Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu [LiteratureReference:8878827] Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly Complex [LiteratureReference:8878791] The Human Iron-Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules [LiteratureReference:9676122] Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis
modified	[InstanceEdit:2395513] May, B, 2012-07-02 [InstanceEdit:2408373] May, B, 2012-07-16 [InstanceEdit:2426693] May, B, 2012-08-08 [InstanceEdit:2463806] May, B, 2012-08-30 [InstanceEdit:2466333] May, B, 2012-09-06 [InstanceEdit:2466352] May, B, 2012-09-06 [InstanceEdit:2473460] May, B, 2012-09-24 [InstanceEdit:2520970] May, B, 2012-10-11 [InstanceEdit:2559593] May, B, 2012-11-02 [InstanceEdit:5255114] May, B, 2014-02-06 [InstanceEdit:8878849] May, Bruce, 2016-07-13 [InstanceEdit:8878850] May, Bruce, 2016-07-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9676129] May, Bruce, 2020-02-10 [InstanceEdit:9676130] May, Bruce, 2020-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster
output	[Complex:1362398] FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] [Homo sapiens] [SimpleEntity:379697] L-Ala [mitochondrial matrix] [SimpleEntity:379697] L-Ala [mitochondrial matrix] [SimpleEntity:379697] L-Ala [mitochondrial matrix] [SimpleEntity:379697] L-Ala [mitochondrial matrix] [DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens] [DefinedSet:2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:1362416] Frataxin binds iron [Homo sapiens] [Reaction:1362417] Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix [Homo sapiens] [Reaction:2395512] FDXR transfers electrons to FDX1,2 (FDX1L) [Homo sapiens] [Reaction:2395517] NADPH transfers electrons to FDXR [Homo sapiens]
regulatedBy	[Requirement:9023934] Requirement by 'FDX1,FDX2 (reduced) [mitochondrial matrix]'
regulationReference	[RegulationReference:9642780] Requirement by 'FDX1,FDX1L (red.) [mitochondrial matrix]' Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis [RegulationReference:9676126] Requirement by 'FDX1,FDX2 (reduced) [mitochondrial matrix]' Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis
releaseDate	2012-12-04
reviewed	[InstanceEdit:2520930] Rouault, Tracey A, 2012-10-11 [InstanceEdit:2520940] Tong, Wing-Hang, 2012-10-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200204] R-HSA-1362408.6
summation	[Summation:1362312] Iron-sulfur clusters are assembled on the scaffold, ISCU. Ba...
(hasEvent)	[Pathway:1362409] Mitochondrial iron-sulfur cluster biogenesis [Homo sapiens]
(precedingEvent)	[Reaction:8878822] Transfer of 2Fe-2S cluster from ISCU to GLRX5 [Homo sapiens] [BlackBoxEvent:9854984] Transfer of Fe-S clusters to SDHB [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777302] Update Tracker - [BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - v72:[addLiteratureReference, modifyText, removeCatalystActivity] [_UpdateTracker:9780416] Update Tracker - [BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - v63:[addRegulator] [_UpdateTracker:9782827] Update Tracker - [BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - v58:[addLiteratureReference]
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No pathways have been reviewed or authored by FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (1362408)