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Query author contributions in Reactome

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Details on Person 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]

Class:IdComplex:1362401
_displayName2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]
_timestamp2019-04-17 21:19:07
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:1362403] May, B, 2011-06-09
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:1362328] Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex
[LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex
[LiteratureReference:1362327] Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones
[LiteratureReference:1362331] Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins
[LiteratureReference:1362323] Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells
[LiteratureReference:1362380] Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia
modified[InstanceEdit:2395496] May, B, 2012-07-02
[InstanceEdit:2395753] May, B, 2012-07-02
[InstanceEdit:2466333] May, B, 2012-09-06
[InstanceEdit:2520970] May, B, 2012-10-11
[InstanceEdit:9644724] D'Eustachio, Peter, 2019-04-17
name2 Iron:FXN:NFS1:ISD11:ISCU
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3203233] R-HSA-1362401.2
(input)[BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster [Homo sapiens]
(output)[Reaction:1362416] Frataxin binds iron [Homo sapiens]
(physicalEntity)[CatalystActivity:1362414] cysteine desulfurase activity of 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]
(updatedInstance)[_UpdateTracker:9900616] Update Tracker - [Complex:1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] - v69:[add_removeHasComponent]
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No pathways have been reviewed or authored by 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] (1362401)
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