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Details on Person FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]

Class:Id	Complex:1362398
_displayName	FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]
_timestamp	2019-04-17 21:19:08
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:1362403] May, B, 2011-06-09
hasComponent	[EntityWithAccessionedSequence:1362391] ISCU-1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362391] ISCU-1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362392] LYRM4 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362392] LYRM4 [mitochondrial matrix] [Homo sapiens] [SimpleEntity:1362383] 2Fe-2S cluster [mitochondrial matrix] [SimpleEntity:1362383] 2Fe-2S cluster [mitochondrial matrix] [EntityWithAccessionedSequence:1362390] FXN(81-210) [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362390] FXN(81-210) [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362396] PXLP-K258-NFS1-1 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:1362396] PXLP-K258-NFS1-1 [mitochondrial matrix] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1362328] Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex [LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex [LiteratureReference:1362327] Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones [LiteratureReference:1362331] Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins [LiteratureReference:1362323] Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells
modified	[InstanceEdit:1362406] May, B, 2011-06-09 [InstanceEdit:2395496] May, B, 2012-07-02 [InstanceEdit:2466333] May, B, 2012-09-06 [InstanceEdit:2520970] May, B, 2012-10-11 [InstanceEdit:9644724] D'Eustachio, Peter, 2019-04-17
name	FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3203669] R-HSA-1362398.2
(input)	[Reaction:5691407] ABCB7 transports ISC from mitochondrial matrix to cytosol [Homo sapiens] [Reaction:8878822] Transfer of 2Fe-2S cluster from ISCU to GLRX5 [Homo sapiens] [BlackBoxEvent:9854984] Transfer of Fe-S clusters to SDHB [Homo sapiens] [Reaction:9866272] 2Fe-2S is inserted in UQCRFS1 [Homo sapiens]
(output)	[BlackBoxEvent:1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster [Homo sapiens]
(physicalEntity)	[CatalystActivity:9866276] iron chaperone activity of FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]
(updatedInstance)	[_UpdateTracker:9900388] Update Tracker - [Complex:1362398] FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] - v69:[add_removeHasComponent]
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No pathways have been reviewed or authored by FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] (1362398)