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Details on Person RNF41 binds neuregulin-activated ERBB3

Class:Id	Reaction:1358798
_displayName	RNF41 binds neuregulin-activated ERBB3
_doRelease	TRUE
_timestamp	2024-03-20 23:47:02
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1358799] Orlic-Milacic, Marija, 2011-06-02
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[EntityWithAccessionedSequence:975977] RNF41 [cytosol] [Homo sapiens] [CandidateSet:1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1358724] Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1
modified	[InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963601] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	RNF41 binds neuregulin-activated ERBB3
negativePrecedingEvent	[NegativePrecedingEvent:9866017] Futile Cycle: Deubiquitination of RNF41 by P-USP8 [NegativePrecedingEvent:9866030] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866033] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 [NegativePrecedingEvent:9866042] Futile Cycle: RNF41 ubiquitinates ERBB3 [NegativePrecedingEvent:9866043] Futile Cycle: RNF41 ubiquitinates activated ERBB3
output	[Complex:1358734] NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016694] R-HSA-1358798.3
summation	[Summation:1358764] In addition to regulating the level of unstimulated ERBB3, u...
(hasEvent)	[Pathway:1358803] Downregulation of ERBB2:ERBB3 signaling [Homo sapiens]
(precedingEvent)	[Reaction:1358792] RNF41 ubiquitinates activated ERBB3 [Homo sapiens]
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