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Details on Person Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
| Class:Id | LiteratureReference:1358728 |
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| _displayName | Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 |
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| _timestamp | 2011-06-02 15:19:24 |
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| author | [Person:1358682] Junttila, TT
[Person:1358661] Akita, Robert W
[Person:1358694] Parsons, K
[Person:1358671] Fields, C
[Person:1358685] Lewis Phillips, GD
[Person:1358675] Friedman, LS
[Person:1358700] Sampath, D
[Person:1181192] Sliwkowski, MX |
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| created | [InstanceEdit:1358723] Orlic-Milacic, Marija, 2011-06-02 |
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| journal | Cancer Cell |
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| pages | 429-40 |
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| pubMedIdentifier | 19411071 |
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| title | Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941 |
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| volume | 15 |
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| year | 2009 |
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| (literatureReference) | [ChemicalDrug:2399804] GDC0941 [cytosol]
[CandidateSet:2399811] PI3K/mutant PI3K inhibitors [cytosol]
[CandidateSet:9732428] PI3K inhibitors [cytosol]
[Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Homo sapiens]
[Reaction:1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Homo sapiens]
[Reaction:2400009] PI3K inhibitors block PI3K catalytic activity [Homo sapiens]
[Reaction:9732513] PI3K inhibitors bind to Activator:PI3K [Homo sapiens]
[Summation:2316435] A number of different extracellular signals converge on PI3K...
[Summation:2404213] A variety of inhibitors capable of blocking the phosphoinosi...
[Summation:9732467] A variety of inhibitors capable of blocking the phosphoinosi... |
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