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Details on Person Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

Class:Id	Reaction:1307963
_displayName	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
_doRelease	TRUE
_timestamp	2011-09-09 09:08:12
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:1307960] protein tyrosine kinase activity of FGFR4:HS:KLB:FGF19 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1307962] Rothfels, K, 2011-05-30
input	[Complex:1307953] FGFR4:HS:KLB:FGF19 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1307940] Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members [LiteratureReference:1307944] Relevant use of Klotho in FGF19 subfamily signaling system in vivo [LiteratureReference:1307949] The Klotho gene family as a regulator of endocrine fibroblast growth factors [LiteratureReference:1307951] Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 [LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction [LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis [LiteratureReference:191025] A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
modified	[InstanceEdit:1498834] Rothfels, K, 2011-08-18 [InstanceEdit:1552993] Matthews, L, 2011-09-04 [InstanceEdit:1580734] Rothfels, K, 2011-09-07 [InstanceEdit:1583037] Rothfels, K, 2011-09-07 [InstanceEdit:1584609] Rothfels, K, 2011-09-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 Autocatalytic phosphorylation of betaKlotho-bound FGFR4
output	[Complex:1307958] Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1307955] FGFR4 binds HS:KLB:FGF19 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591462] R-HSA-1307963.2
summation	[Summation:1307961] After being bound by BetaKlotho and FGF19, FGFR4 undergoes a...
(hasEvent)	[Pathway:1307965] betaKlotho-mediated ligand binding [Homo sapiens]
(precedingEvent)	[Reaction:5654163] Activated FGFR4 binds PLCG1 [Homo sapiens] [Reaction:5654422] Activated FGFR4 binds FRS2 [Homo sapiens] [Reaction:5654425] Activated FGFR4 binds SHC1 [Homo sapiens] [Reaction:5654651] Activated FGFR4 binds FRS3 [Homo sapiens]
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No pathways have been reviewed or authored by Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (1307963)